Clinical and Multimodal Imaging Clues in Differentiating Between Tuberculomas and Sarcoid Choroidal Granulomas

Purpose To compare the differences among clinical, demographic, and multimodal imaging features of choroidal granulomas associated with tuberculosis sarcoidosis. Design Retrospective comparative case series. Methods Clinical fundus imaging, including fluorescein indocyanine green angiography optical coherence tomography patients tuberculomas sarcoid seen at 3 tertiary care centers, were reviewed. The clinical appearances, morphology lesions (size, shape, extent), vascularity, features, compared. Repeated logistic regression measurements a multilevel random effects model was used to assess characteristics individual that could predict underlying cause. Results study included 47 eyes 38 (22 16 granulomas; total 138 granulomas). Patients significantly younger (33.8 ± 10.1 vs. 48.6 14.3 years, respectively; P = .002), but no sex observed. In comparison granulomas, solitary (P <.001), intense yellow, lobulated, full thickness, located in perivascular region (all <.001); they also larger (16.01 9.7 mm2 2.7 4.5 mm2, <.001) vascularized <.001). Sarcoid retinal vasculitis .003) disc hyperfluorescence Logistic showed multiple sarcoidosis (odds ratio [OR]: 3.5; 95% confidence interval: 1.8-6.9; Granulomas than 6.45 had highest area under receiver operating curves (0.94) for differentiating from granulomas. Conclusions Tuberculomas have various help differentiate between 2 entities high predictability can supplement immunological radiological tests diagnosis.